以HLAⅡ类转基因鼠研究类风湿关节炎的发病机制

类风湿关节炎（RA）是一种常见的慢性自身免疫性疾病,至今发病原因不明。许多研究表明遗传因素是导致RA发病的最主要原因,而在遗传因素中约35%来自于人类白细胞抗原（HLA）Ⅱ类复合体。因此,对于HLA Ⅱ类复合体参与RA发病的分子机制研究一直是人们关注的热点,而表达HLA Ⅱ类分子的转基因鼠是研究HLA Ⅱ类复合体与RA发病关系最佳的平台。目前,国外已建立了几个HLA Ⅱ类转基因鼠品系,为RA发病机制的研究奠定了很好的基础。本文对HLA Ⅱ类转基因鼠及以此为基础的RA相关研究进行综述。

Research on the Pathogenesis of Rheumatoid Arthritis Using Human Leukocyte Antigen Class Ⅱ Transgenic Mice

Rheumatoid arthritis （RA） is a common chronic autoimmune disease. Its etiology is not yet clear. Evidence for a strong inherited component in RA is supported by a lot of data, and about 35 % of genetic contribution to RA can be attributed to human leukocyte antigen class Ⅱ complex. Therefore, the molecular basis of HLA Ⅱ genes in the pathogenesis of RA is a most attracting issue. The HLA Ⅱ transgenic mice are an ideal platform for studying the association between HLA Ⅱ genes and RA. Up to date, several kinds of HLA Ⅱ transgenic mice have been constructed, and great effort has been made to elucidate the HLA Ⅱ associated RA susceptibility. In the present paper, we focus on HLA Ⅱ transgenic mice and review the progress made related to the molecular mechanism of RA.