Metabolism of monofluorobenzoates by Acinetobacter calcoaceticus N.C.I.B. 8250 formation of monofluorocatechols |
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Authors: | KF Clarke AG Callely A Livingstone CA Fewson |
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Institution: | 1. Coalite and Chemical Products Ltd., P.O. Box No. 21, Chesterfield, S44 6AB, UK;2. Department of Microbiology, University College, Newport Road, Cathays Park, Cardiff CF2 1TA, UK;3. Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ U.K. |
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Abstract: | None of the monofluorobenzoates serves as sole source of carbon and energy for growth of Acinetobacter calcoaceticus but all can contribute to growth on other substrates. The monofluorobenzoates are oxidised by bacteria pre-induced for benzoate oxidation and can themselves induce the appropriate enzymes. The initial products of oxidation have been separated and identified by gas-liquid chromatography. 2-Fluorobenzoate is oxidised to catechol, fluoride and 3-fluorocatechol; 3-fluorobenzoate gives 3- and 4-fluorocatechol; 4-fluorobenzoate gives 4-fluorocatechol. The fluorocatechols appear to be partially oxidised beyond the stage of 3-oxoadipate by suitably pre-induced bacteria. |
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