Evolution of Rh Blood Group Genes Have Experienced Gene Conversions and Positive Selection |
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Authors: | Takashi Kitano Naruya Saitou |
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Institution: | (1) Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima, 411-8540, Japan, JP |
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Abstract: | There are two tightly linked loci (D and CE) for the human Rh blood group. Their gene products are membrane proteins having
12 transmembrane domains and form a complex with Rh50 glycoprotein on erythrocytes. We constructed phylogenetic networks of
human and nonhuman primate Rh genes, and the network patterns suggested the occurrences of gene conversions. We therefore
used a modified site-by-site reconstruction method by using two assumed gene trees and detected 9 or 11 converted regions.
After eliminating the effect of gene conversions, we estimated numbers of nonsynonymous and synonymous substitutions for each
branch of both trees. Whichever gene tree we selected the branch connecting hominoids and Old World monkeys showed significantly
higher nonsynonymous than synonymous substitutions, an indication of positive selection. Many other branches also showed higher
nonsynonymous than synonymous substitutions; this suggests that the Rh genes have experienced some kind of positive selection.
Received: 16 March 1999 / Accepted: 17 June 1999 |
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Keywords: | : Rh blood group — gene conversion — positive selection |
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