Putative therapeutic agents for the learning and memory deficits of people with Down syndrome |
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Authors: | Kim Nam Doo Yoon Jeonghyeok Kim Jung Ho Lee Jung Tae Chon Yong Sog Hwang Mi-Kyung Ha Ilho Song Woo-Joo |
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Affiliation: | Research Center IDRTech Inc., 3rd FL., Chosun Refractory Building, 4-1, Sunae-Dong, Bundang-Ku, Sungnam-Shi, Kyunggi-Do 463-825, South Korea. |
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Abstract: | Mental retardation is the most common and debilitating condition for individuals with Down syndrome (DS). The hyper-activation of DYRK1A by overexpression causes significant learning and memory deficits in DS-model mice. Thus far, no mechanism-based drug has been developed to address this. After a combination of in silico and in vitro screenings, two DYRK1A inhibitors were isolated that are active in a cell-based assay. Further optimization could lead to a novel drug discovery that could address DS learning and memory deficits. |
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