| 双特异性纳米抗体的研究进展及其应用 |
| |
| 引用本文： | 原博,王杰文,康广博,黄鹤. 双特异性纳米抗体的研究进展及其应用[J]. 中国生物工程杂志, 2021, 0(2): 78-88 |
| |
| 作者姓名： | 原博 王杰文 康广博 黄鹤 |
| |
| 作者单位： | 天津大学生物化学工程系化学工程学院;天津大学系统生物工程教育部重点实验室 |
| |
| 基金项目： | 国家重点研发计划(2019YFA0905600);天津科技计划(19YFSLQY00110)资助项目。 |
| |
| 摘 要： | 从纳米抗体的研究进展,双特异性纳米抗体在感染类疾病、肿瘤以及免疫系统疾病治疗领域的研究成果、研究热点及发展前景等方面综述了双特异性纳米抗体的研究进展并分析了未来可能的发展方向.首先比较了纳米抗体与全长单克隆抗体之间的差异并阐述了双特异性纳米抗体具备的独特优势;继而概括了双特异性纳米抗体的发展历程,并对新冠病毒的中和性抗...
|
| 关 键 词： | 纳米抗体 双特异性抗体 感染性疾病 肿瘤治疗 免疫性疾病 |
Research Progress and Application of Bispecific Nanobody |
| |
| YUAN Bo,WANG Jie-wen,KANG Guang-bo,HUANG He. Research Progress and Application of Bispecific Nanobody[J]. China Biotechnology, 2021, 0(2): 78-88 |
| |
| Authors: | YUAN Bo WANG Jie-wen KANG Guang-bo HUANG He |
| |
| Affiliation: | (Department of Biochemical Engineering,School of Chemical Engineering and Technology,Tianjin Universily,Tianjn 300350,China;Key Laboratory of Systems Bioengineering of Ministry of Education,Tianjin Univrsity,Tianjin 30002.China) |
| |
| Abstract: | This article reviews the application and advances of bispecific nanobodies from the research progress of nanobodies and studies of bispecific nanobodies in treating infectious diseases,cancer,and immune system diseases.Moreover,it highlights the research hotspots and potential research areas at this current stage.For in-depth analysis,the differences between nanobodies and full-length monoclonal antibodies are compared and the unique advantages of bispecific nanobodies are demonstrated.The research progress of nanobodies has been summarized,while emphasizing the research hot spots of neutralizing nanobodies of the COVID-19,CAR-T cell therapy,and immune checkpoint therapy antibodies.In conclusion,a prospect analysis of the application prospects of bispecific nanobodies is carried out.It is pointed out that bispecific nanobodies are able to overcome the shortcomings of full-length antibody and become a form of the antibody with great druggability. |
| |
| Keywords: | Nanobody Bispecific antibody Infectious diseases Tumor therapy Immune diseases |
| 本文献已被 维普 等数据库收录！ |
|
