Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm. |
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| Authors: | J. Eliza P. Daisy S. Ignacimuthu |
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| Affiliation: | 1. Department of Biotechnology, Holy Cross College, Trichy 620002, Tamil Nadu, India;2. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai 600034, Tamil Nadu, India;1. Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México;2. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México;3. Unidad Académica Multidisciplinaria de la Zona Huasteca, Universidad Autónoma de San Luis Potosí, Ciudad Valles, San Luis Potosí, México;4. El colegio de la Frontera Sur unidad San Cristóbal, San Cristóbal de las Casas, Chiapas, México;1. Department of Life and Reproduction Sciences, Section of Biochemistry, University of Verona, Verona, Italy;2. Department of Biological and Environmental Sciences, University of Messina, 98166 Messina, Italy;3. Manchester University, Manchester, United Kingdom;1. Department of Pharmacy, Logistics College of Chinese People''s Armed Police Forces, Tianjin 300162, China;2. Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazard. Logistics College of Chinese People’s Armed Police Forces, Tianjin 300162, China;3. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;4. The State Key Laboratories of Pharmacodynamics and Pharmacokinetics, Tianjin 300193, China;1. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;2. Chengdu University of Traditional Chinese Medicine, Chengdu, China |
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| Abstract: | Antioxidant properties of many medicinal plants have been widely recognized and some of them have been commercially exploited. Plant derived antioxidants play a very important role in alleviating problems related to oxidative stress. The present study was aimed at assessing the antioxidant property of costunolide and eremanthin isolated from a medicinal plant Costus speciosus (Koen ex. Retz) Sm. rhizome. Experimental diabetes was induced by a single dose of STZ (60 mg/kg, i.p.) injection. The oxidative stress was measured by tissue thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) content and enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in brain, liver, heart, kidney and pancreas. An increase in TBARS level, a significant reduction in GSH content along with decreased enzymatic activities of SOD, CAT, and GPx were seen in untreated diabetic rats. Administration of either costunolide (20 mg/kg day) or eremanthin (20 mg/kg day) for 60 days caused a significant reduction in TBARS level and a significant increase in GSH content along with increased enzymatic activities of SOD, CAT and GPx in the treated rats when compared to untreated diabetic rats. Acute toxicity test revealed the non-toxic nature of the compounds. The results indicated for the first time the protective effect of costunolide and eremanthin from oxidative stress, thus opening the way for their use in medication. |
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