Genotoxicity studies with four organophosphorus insecticides using the unstable white-zeste system of Drosophila melanogaster |
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| Authors: | N Xamena A Velázquez M Batiste-Alentorn A Creus R Marcos |
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| Institution: | Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. |
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| Abstract: | The present study was carried out to evaluate the suitability of the unstable white-zeste system in Drosophila melanogaster by testing 4 organophosphorus insecticides for potential genotoxic activity: dimethoate, fenitrothion, malathion, and methyl parathion. In view of the high sensitivity to insecticides of the unstable zeste strain used in this assay and the negative results obtained in this work, the white-zeste system does not appear to be sufficiently accurate for the evaluation of the mutagenic potential of specifically toxic chemicals, like insecticides. |
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