Notch信号通路对免疫细胞的调节作用

Notch家族是一组进化上高度保守的跨膜蛋白，可以广泛调节细胞的发育和分化.越来越多的研究发现，Notch信号通路可以通过调节多种免疫细胞的发育和功能来调节机体的免疫功能.本文综述了Notch家族的组成，其调控因素及其靶基因，Notch信号通路对造血干细胞、固有免疫细胞和适应性免疫细胞的调节作用以及Notch信号通路参与的免疫相关疾病.Notch信号通路对造血干细胞、巨噬细胞、树突状细胞、肥大细胞、T和B淋巴细胞的发育和功能的发挥都有重要的调节作用，并参与肿瘤、病毒感染、炎症反应和自身免疫疾病等免疫相关疾病的发生.

Regulatory Roles of Notch Signaling in Immune Cells

Notch family is a series of highly conserved proteins.Notch regulates a broad spectrum of cell development and differentiation. More and more recent studies have addressed the role of Notch signaling on immunity by regulating multiple immune cells. This article reviewed the composition of Notch family, its regulatory factors and target genes, the regulation of Notch signaling on haematopoietic stem cells, innate immune and adaptive immune related immune cells. In conclusion, Notch signaling play very important roles in the development and functioning of haematopoietic stem cells, macrophages, dendritic cells, mast cells,T and B lymphocytes, as well as the genesis of immune related diseases including cancer，virus infection, inflammation and autoimmune diseases.