Modulation of multidrug resistance in tumor cells by taxinine derivatives |
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| Authors: | Hosoyama H Shigemori H Tomida A Tsuruo T Kobayashi J |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. |
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| Abstract: | 
Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells. |
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