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A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury |
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| Authors: | Fazile Nur Ekinci Akdemir Berna Karagöz Recep Soslu Saleh H Alwasel |
| Institution: | 1. Department of Nutrition and Dietetics, Health School, A?r? ?brahim ?e?en University, A?ri, Turkey,;2. Department of Pharmacology, Faculty of Pharmacy, A?r? ?brahim ?e?en University, A?ri, Turkey, and;3. Physical Education and Sports, Bart?n University, Bartin, Turkey;4. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia, |
| Abstract: | AbstractThe antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2?h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2?h. EA (100?mg/kg) has been applied orally before ischemia/reperfusion in the EA?+?I/R group. HES (100?mg/kg) has been given orally in the HES?+?I/R group. The left gastrocnemius muscle has been harvested and stored immediately at??80?°C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p?<?0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p?<?0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA?+?I/R and HES?+?I/R groups. |
| Keywords: | Antioxidant activity ellagic acid hesperidin ischemia/reperfusion injury skeletal muscle |