Diterpenoids from Acanthopanax brachypus Harms |
| |
| Authors: | Hao‐Bin Hu Xu‐Dong Zheng Huai‐Sheng Hu Yun Wu |
| |
| Institution: | 1. College of Chemistry & Chemical Engineering, Longdong University, Qingyang 745000, P.?R. China, (phone: +86‐934‐8658532;2. fax: +86‐934‐8651531) |
| |
| Abstract: | Four diterpenoids, including two new ones, namely noracanthopanin A ( 1 ) and acanthopanolide B ( 2 ), and two known ones, ent‐pimara‐9(11),15‐dien‐19‐oic acid ( 3 ) and ent‐kaur‐16‐en‐19‐oic acid ( 4 ), were isolated from the stem bark of Acanthopanax brachypus Harms . Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO‐8910 cells with IC50 values of 65.21±0.23 and 31.43±1.01 μg/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC‐7721 cells (IC50 89.67±2.54 μg/ml). |
| |
| Keywords: | Acanthopanax brachypus Diterpenoids Noracanthopanin A Acanthopanolide B Cytotoxic activity |
|
|
