Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar |
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| Authors: | Yumin Dai Liva Harinantenaina Peggy J Brodie Chris Birkinshaw Richard Randrianaivo Wendy Applequist Michel Ratsimbason Vincent E Rasamison Yongchun Shen Karen TenDyke David G I Kingston |
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| Institution: | 1. Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, USA (phone: +1‐540‐231‐6570);2. Missouri Botanical Garden, B.P. 3391, Antananarivo 101, Madagascar;3. Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166?–?0299, USA;4. Centre National d'Application des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar;5. Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA |
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| Abstract: | Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin ( 1 ), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin ( 2 ) and 6″‐O‐acetylrandianin ( 3 ). The structures of the two new compounds were elucidated based on analysis of their 1D‐ and 2D‐NMR spectra, and mass spectrometric data. The three isolated triterpene saponins displayed moderate but selective antiproliferative activities, with IC50 values of 1.2, 1.7, and 2.2 μM , respectively, against the A2780 ovarian cancer, but only weak inhibitions of the proliferation of A2058 melanoma and the H522 lung cancer cell lines. |
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| Keywords: | Nematostylis anthophylla Triterpene saponins Saponins Antiproliferative activity |
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