Improved Chiral SFC Screening for Analytical Method Development |
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| Authors: | Wes Schafer Tilak Chandrasekaran Zainab Pirzada Chaowei Zhang Xiaoyi Gong Mirlinda Biba Erik L Regalado Christopher J Welch |
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| Institution: | Analytical Chemistry, Merck Research Laboratories, , Rahway, New Jersey |
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| Abstract: | In this study we describe the evaluation of a recently developed supercritical fluid chromatography (SFC) instrument for automated chiral SFC method development. The greatly improved gradient dwell volume and liquid flow control of the new instrument in combination with the use of shorter columns containing smaller stationary phase particles affords chiral SFC method development that is faster and more universal than previous systems. Chirality 25:799–804, 2013. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | SFC chiral screening method development fast analysis |
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