Changes in sulfated mucopolysaccharide composition of mammalian tissues during growth and in cancer tissues |
| |
Authors: | Lúcia O Sampaio Carl P Dietrich Osvaldo Giannotti Filho |
| |
Institution: | Departamento de Bioquímica e Farmacologia, Escola Paulista de Medicina, C.P. 20372, São Paulo, SP, Brazil |
| |
Abstract: | The distribution of sulfated mucopolysaccharides in different tissues during growth and in cancer tissues is reported. It is shown that most of the tissues of 1 day-old rats and rabbits contain chondroitin sulfate A/C, chonroitin sulfate B and heparan sulfate in about the same proportions, whereas in adult animals chondroitin sulfate A/C decreases in concentration or disappears. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tissues. In rats, these changes occur in the first 25 days of extrauterine development. A great increase of chondoitin sulfate A/C was observed in human tumors of different origins when compared with the normal adjacent tissues. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tumors analysed. The possible role of chondroitin sulfate A/C in cell division is discussed in view of the present findings. |
| |
Keywords: | chondroitin sulfate A chondoritin 4-sulfate chondroitin sulfate B dermatan sulfate chondroitin sulfate C chondroitin 6-sulfate ΔDi-4S ΔDi-6S |
本文献已被 ScienceDirect 等数据库收录! |