Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions |
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| Authors: | Shannan Cao Peng Liu Haiyan Zhu Haiyan Gong Jianfeng Yao Yawei Sun Guangfeng Geng Tong Wang Sizhou Feng Mingzhe Han Jiaxi Zhou Yuanfu Xu |
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| Affiliation: | 1State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;2Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China;University Hospital Basel, SWITZERLAND |
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| Abstract: | ![]()
In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions. |
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