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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
Authors:Elizabeth A. Bowling  Jarey H. Wang  Fade Gong  William Wu  Nicholas J. Neill  Ik Sun Kim  Siddhartha Tyagi  Mayra Orellana  Sarah J. Kurley  Rocio Dominguez-Vidaña  Hsiang-Ching Chung  Tiffany Y.-T. Hsu  Julien Dubrulle  Alexander B. Saltzman  Heyuan Li  Jitendra K. Meena  Gino M. Canlas  Srinivas Chamakuri  Thomas F. Westbrook
Affiliation:1. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA;2. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA;3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;4. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA;5. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA;6. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;7. Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA;8. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA;9. H3Biomedicine, Cambridge, MA 02139, USA
Abstract:
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  • Keywords:RNA splicing in cancer  triple-negative breast cancer  spliceosome-targeted therapies  viral mimicry  antiviral immunity  anti-cancer immunity  MYC  double-stranded RNA  oncogenic stress
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