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Reducing acetylated tau is neuroprotective in brain injury
Authors:Min-Kyoo Shin  Edwin Vázquez-Rosa  Yeojung Koh  Matasha Dhar  Kalyani Chaubey  Coral J. Cintrón-Pérez  Sarah Barker  Emiko Miller  Kathryn Franke  Maria F. Noterman  Divya Seth  Rachael S. Allen  Cara T. Motz  Sriganesh Ramachandra Rao  Lara A. Skelton  Machelle T. Pardue  Steven J. Fliesler  Chao Wang  Andrew A. Pieper
Affiliation:1. Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;2. Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA;3. Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center; Cleveland, OH, USA;4. Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA;5. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA;6. Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;7. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Atlanta, GA, USA;8. Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, US;9. Departments of Ophthalmology and Biochemistry, and the Neuroscience Graduate Program, SUNY-University at Buffalo, Buffalo, NY, USA;10. Research Service, VA Western NY Healthcare System, Buffalo, NY, USA;11. Gladstone Institute of Neurological Disease, San Francisco, CA, USA;12. The Buck Institute, Novato, CA, USA;13. Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine, New York, NY, USA;14. The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA;15. Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA;16. Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA;17. Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA;18. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;19. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA;20. MetroHealth Rehabilitation Institute, The MetroHealth System, Cleveland, OH;21. Department of Physical Medicine and Rehabilitation, Case Western Reserve University, School of Medicine, Cleveland, OH USA;22. Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;23. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;24. Department of Pathology, Northwestern University, Chicago, IL, USA;25. Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA;26. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA;27. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA;28. Departments of Anesthesiology & Perioperative Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;29. Weill Cornell Autism Research Program, Weill Cornell Medicine of Cornell University, New York, NY, USA;30. Department of Neuroscience, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
Abstract:
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  • Keywords:neuroprotection  traumatic brain injury  Alzheimer’s disease  acetylation  tau  neurodegeneration  omigapil  congenital muscular dystrophy  salsalate  diflunisal  P7C3
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