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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Authors:Zeyu Chen  Eri Arai  Omar Khan  Zhen Zhang  Shin Foong Ngiow  Yuan He  Hua Huang  Sasikanth Manne  Zhendong Cao  Amy E. Baxter  Zhangying Cai  Elizabeth Freilich  Mohammed A. Ali  Josephine R. Giles  Jennifer E. Wu  Allison R. Greenplate  Mohamed A. Hakeem  Qingzhou Chen  Junwei Shi
Affiliation:1. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;2. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;5. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;6. Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA;7. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA;8. Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
Abstract:
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  • Keywords:CRISPR  CD8  exhaustion  immunotherapy  Fli1  protective immunity  effector CD8 T cell  exhausted CD8 T cell  cancer  chronic infection
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