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A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
Authors:Harikesh S. Wong  Kyemyung Park  Anita Gola  Antonio P. Baptista  Christine H. Miller  Deeksha Deep  Meng Lou  Lisa F. Boyd  Alexander Y. Rudensky  Peter A. Savage  Grégoire Altan-Bonnet  John S. Tsang  Ronald N. Germain
Affiliation:1. Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA;2. Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA;3. Biophysics program, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA;4. Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGhent Center for Inflammation Research, Ghent University, 9052 Ghent, Belgium;5. Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium;6. Department of Pathology, University of Chicago, Chicago, IL 60637, USA;7. Howard Hughes Medical Institute, Immunology Program and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA;8. Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;9. Immunodynamics Group, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Abstract:
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  • Keywords:immune homeostasis  autoimmunity  regulatory T cells  quantitative tissue imaging  feedback control  computational modeling  IL-2  IL-2Rα  CTLA-4  apoptosis
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