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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Authors:Stefan C Dentro  Ignaty Leshchiner  Kerstin Haase  Maxime Tarabichi  Jeff Wintersinger  Amit G Deshwar  Kaixian Yu  Yulia Rubanova  Geoff Macintyre  Jonas Demeulemeester  Ignacio Vázquez-García  Kortine Kleinheinz  Dimitri G Livitz  Salem Malikic  Nilgun Donmez  Subhajit Sengupta  Pavana Anur  Clemency Jolly  Peter Van Loo
Institution:1. Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK;2. Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK;3. Big Data Institute, University of Oxford, Oxford OX3 7LF, UK;4. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. University of Toronto, Toronto, ON M5S 3E1, Canada;6. Vector Institute, Toronto, ON M5G 1L7, Canada;7. The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;8. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK;9. Department of Human Genetics, University of Leuven, 3000 Leuven, Belgium;10. University of Cambridge, Cambridge CB2 0QQ, UK;11. Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;12. Irving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA;13. German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;14. Heidelberg University, 69120 Heidelberg, Germany;15. Cancer Data Science Laboratory, National Cancer Institute, NIH, Bethesda, MD 20892, USA;16. Simon Fraser University, Burnaby, BC V5A 1S6, Canada;17. Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada;18. NorthShore University HealthSystem, Evanston, IL 60201, USA;19. Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97231, USA;20. University of Melbourne, Melbourne, VIC 3010, Australia;21. Walter + Eliza Hall Institute, Melbourne, VIC 3000, Australia;22. Weill Cornell Medicine, New York, NY 10065, USA;23. New York Genome Center, New York, NY 10013, USA;24. Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK;25. University of California, Santa Cruz, Santa Cruz, CA 95064, USA;26. Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6BT, UK;27. Cancer Genome Evolution Research Group, University College London Cancer Institute, London WC1E 6DD, UK;28. Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK;29. Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129, USA;30. Massachusetts General Hospital, Department of Pathology, Boston, MA 02114, USA;31. Harvard Medical School, Boston, MA 02215, USA;32. Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;33. University of California, Los Angeles, Los Angeles, CA 90095, USA;34. Dana-Farber Cancer Institute, Boston, MA 02215, USA;35. The University of Chicago, Chicago, IL 60637, USA;36. Department of Translational Genomics, Center for Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany;37. Organismal and Evolutionary Biology Research Programme, Department of Computer Science, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland;38. School of Computing Science, University of Glasgow, Glasgow G12 8RZ, UK;39. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge CB10 1SD, UK;40. European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany;41. Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;42. Oxford NIHR Biomedical Research Centre, Oxford OX4 2PG, UK;43. Manchester Cancer Research Centre, University of Manchester, Manchester M20 4GJ, UK
Abstract:
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  • Keywords:whole-genome sequencing  pan-cancer genomics  intra-tumor heterogeneity  cancer driver genes  cancer evolution  tumor phylogeny  subclonal reconstruction  branching evolution
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