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BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
Authors:Richard J. Mills  Sean J. Humphrey  Patrick R.J. Fortuna  Mary Lor  Simon R. Foster  Gregory A. Quaife-Ryan  Rebecca L. Johnston  Troy Dumenil  Cameron Bishop  Rajeev Rudraraju  Daniel J. Rawle  Thuy Le  Wei Zhao  Leo Lee  Charley Mackenzie-Kludas  Neda R. Mehdiabadi  Christopher Halliday  Dean Gilham  James E. Hudson
Affiliation:1. QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia;2. Charles Perkins Centre, School of Life and Environmental Science, The University of Sydney, Sydney 2006, NSW, Australia;3. The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, VIC, Australia;4. Department of Microbiology and Immunology, The University of Melbourne, Melbourne 3052, VIC, Australia;5. The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, VIC, Australia;6. Murdoch Children’s Research Institute, The Royal Children’s Hospital, Melbourne 3052, VIC, Australia;7. Resverlogix Corp., Calgary T3E 6L1, AB, Canada;8. Victorian Heart Hospital, Monash University, Clayton 3168, VIC, Australia;9. Resverlogix Corp., San Francisco, CA 94104, USA;10. Preclinical Imaging Facility, Translational Research Institute, Brisbane, QLD, Australia;11. Department of Paediatrics, The University of Melbourne, Melbourne 3052, VIC, Australia;12. Dynomics Inc., San Mateo, CA 94401, USA;13. Dynomics Pty Ltd, Brisbane 4000, QLD, Australia;14. Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne 3004, VIC, Australia;15. Department of Infectious Diseases, Monash Medical Centre, Clayton 3168, VIC, Australia;16. GVN Center of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia;17. Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Melbourne 3052, VIC, Australia;18. Institute of Experimental Oncology, University Hospital Bonn, Bonn 53127, Germany;19. Faculty of Medicine and Health, The University of Sydney, Sydney 2006, NSW, Australia
Abstract:
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  • Keywords:inflammation  COVID-19  organoids  heart  drug discovery  Bromodomain and extraterminal family inhibitors
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