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Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1) |
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| Authors: | Rowbottom Martin W Vickers Troy D Tamiya Junko Zhang Mingzhu Dyck Brian Grey Jonathan Schwarz David Heise Christopher E Hedrick Michael Wen Jenny Tang Hui Wang Hua Fisher Andrew Aparicio Anna Saunders John Goodfellow Val S |
| Affiliation: | Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA. mrowbottom@neurocrine.com |
| Abstract: | The design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1. |
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