单耳堵塞对蝙蝠下丘GABA阳性反应神经元的影响

已有的研究表明，单耳堵塞可以使中脑下丘神经元的听空间反应特性改变，而神经元听空间特性的形成与中枢中的周边抑制有关，是神经元的兴奋性中心区域与抑制性周边区域相互作用的结果［１］。γ－氨基丁酸（Ｇａｍｍａ－ａｍｉｎｏｂｙｔｒｉｃａｃｉｄ，ＧＡＢＡ）作为中...

EFFECTS OF MONAURAL PLUGGING ON THE GABA-IMMUNOPOSITIVE NEURONS IN THE INFERIOR COLLICULUS OF BAT,MYOTIS CHINENSIS

In order to explore the mechanism for changes of auditory spatial response properties of inferior collicular(IC) neurons after monaural plugging, we studied effects of monaural plugging on the GABA-immunopositive neurons in the central nucleus of inferior colliculus(ICc) of bat, Myotis chinensis using immunohistochemical technique. The results show that the number of GABA-immunopositive neurons in the ICc contralateral to the plugged ear decreased markedly(P<0.05) but there were no changes in the sizes and shapes of GABA-immunopositive neurons. These data suggest that postnatal early monaural plugging can cause the decrease of GABAergic inhibition in the ICc. Because the auditory spatial response properties of neuron relate to center-surround inhibition, the decrease of inhibition can cause the changes of auditory spatial response properties. Thus,we believe that the changes of auditory spatial response properties of IC neurons may be caused mainly by the decrease of GABAergic inhibition after monaural plugging.