Retromer retrieves wntless |
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| Authors: | Eaton Suzanne |
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| Affiliation: | Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse-108, Dresden 01307, Germany. eaton@mpi-cbg.de |
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| Abstract: | ![]()
Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired. |
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