Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Authors:	Chuan Shih Lillian L. Habeck Laurane G. Mendelsohn Victor J. Chen Richard M. Schultz

Affiliation:	^aLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285,USA

Abstract:

Keywords:	Abbreviations: r, recombinant h, human m, murine TS, thymidylate synthase DHFR, dihydrofolate reductase GARFT, glycinamide ribonucleotide formyltransferase AICARFT, aminoimidazole carboxamide ribonucleotide formyltransferase (EC 2.1.2.3) C1-S, C1 tetrahydrofolate synthase D/C, the protein domain of C1-S containing the 5 10-methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and 5,10-methenyltetrahydrofolate cyclohydrolase activities D/C/S, the full length enzyme of C1-S containing 5 10-methylenetetrahydrofolate dehydrogenase, 5 10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activities (EC 6.3.4.3) FPGS, folylpolyglutamate synthetase HEPES, N-[2-hydroxyethyl]piperazine-N′-[2-ethanesulfonic acid] MTT,3-[4 5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide DDATHF, 5 10-dideazatetrahydrofolic acid Lometrexol, 6R-DDATHF ME, mercaptoethanol NADPH, β-nicotinamide adenine dinucleotide phosphate reduced form ATP, adenosine 5′-triphosphate 6R-MTHF, 6[R]-5 10-methylene-5,6 7,8-tetrahydrofolate LY231514, N-[4-[2-(2-amino-3 4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-L-glutamic acid MTA, multitargeted antifolate
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏