补肺通络解毒汤联合培美曲塞治疗肺癌的效果及对患者趋化因子受体的影响

目的:探讨补肺通络解毒汤联合培美曲塞治疗肺癌的效果及对患者趋化因子受体的影响。方法:选取2016年4月-2018年5月期间我院收治的肺癌患者78例,依据不同的治疗方法随即分为对照组和研究组,对照组采用培美曲塞+顺铂治疗,研究组在其基础上联合应用补肺通络解毒汤治疗,统计对比两组患者的治疗效果及不良反应的发生情况,对比两组患者治疗前后的生活质量,对比两组患者治疗后癌组织中CCR7和CXCR4的表达情况。结果:治疗过程中,研究组患者的头晕头痛、呕吐恶心、肝损伤的发生率低于对照组(P0.05);治疗前两组患者的生活质量没有明显的差异(P0.05),治疗后均得到提高,研究组患者的躯体、生理、心理和社会等功能评分明显高于对照组(P0.05);治疗后,研究组和对照组患者的缓解率分别为51.28%、28.21%,研究组高于对照组(P0.05);研究组患者癌组织中趋化因子受体CCR7和CXCR4的阳性表达率低于对照组(P0.05)。结论:采用补肺通络解毒汤联合培美曲塞+顺铂治疗肺癌,可以有效减少患者在治疗过程中发生的不良反应,提高生活质量,改善趋化因子受体的表达,控制和缓解病情。

The Effect of Bufei Tongluo Jiedu Decoction Combined with Pemetrexed in the Treatment of Lung Cancer and Its Effect on Chemokine Receptor

ABSTRACT Objective: To explore the effect of Bufei Tongluo Jiedu decoction combined with pemetrexed in the treatment of lung cancer and its effect on chemokine receptor. Methods: 78 lung cancer patients admitted to our hospital from April 2016 to may 2018 were selected, according to the different treatment methods, they were divided into control group and study group, the control group treated with pemetrexed and cisplatin treatment, the study group treated with Bufei Tongluo Jiedu decoction on the basis of control group. The treatment effect and adverse reactions of the two groups were compared, the quality of life of the two groups before and after treatment was compared, and the expression of CCR7 and CXCR4 in the cancer tissue of the two groups after treatment was compared. Results: The incidence rate of the adverse reactions like dizziness and headache, emesis and nausea and liver injury for study group was lower than than in the control group(P<0.05). Before treatment, the life quality for two groups was not significantly different(P>0.05), after treatment, the physical function, physiological function, psychological function and social function for study group were significantly higher than that in the control group(P<0.05). After treatment, The remission rates of the study group and the control group were 51.28% and 28.21% respectively, the study group was higher than than in the control group(P<0.05). The positive expression rate of CCR7 and CXCR4 in cancer tissue of the study group was lower than that of the control group(P<0.05). Conclusion: Bufei Tongluo Jiedu decoction combined with pemetrexed and cisplatin can effectively reduce the adverse reactions during the treatment, improve the quality of life, improve the expression of chemokine receptor, control and alleviate the disease.