Epigenetic reprogramming in the mammalian embryo: struggle of the clones |
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| Authors: | Mellissa RW Mann Marisa S Bartolomei |
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| Affiliation: | (1) Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 19104 Philadelphia, PA, USA; |
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| Abstract: | ![]()
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos. |
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