| Institution: | 1.Department of Biochemistry, School of Life Sciences,Bharathidasan University,Tiruchirappalli,India;2.Food Animal Health Research Program, Ohio Agricultural Research and Development Center,The Ohio State University,Wooster,USA;3.Division of Drug Research/Clinical Pharmacology, Department of Medical and Health Sciences,Link?ping University Hospital,Link?ping,Sweden;4.Department of Cellular and Molecular Biochemistry,Frontier Mediville (A Unit of Frontier Lifeline and Dr. K. M. Cherian Heart Foundation), Affiliated to University of Madras,Chennai,India |
| Abstract: | ObjectivesCopper oxide nanoparticles (CuO NPs) promoting anticancer activity may be due to the regulation of various classes of histone deacetylases (HDACs).ResultsGreen-synthesized CuO NPs significantly arrested total HDAC level and also suppressed class I, II and IV HDACs mRNA expression in A549 cells. A549 cells treated with CuO NPs downregulated oncogenes and upregulated tumor suppressor protein expression. CuO NPs positively regulated both mitochondrial and death receptor-mediated apoptosis caspase cascade pathway in A549 cells.ConclusionGreen-synthesized CuO NPs inhibited HDAC and therefore shown apoptosis mediated anticancer activity in A549 lung cancer cell line. |
