Bacteria of the Burkholderia cepacia complex are cyanogenic under biofilm and colonial growth conditions |
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Authors: | Ben Ryall Xiaoyun Lee James EA Zlosnik Saiko Hoshino Huw D Williams |
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Affiliation: | (1) Department of Life Sciences, Division of Biology, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ London, UK |
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Abstract: | Background The Burkholderia cepacia complex (Bcc) is a collection of nine genotypically distinct but phenotypically similar species. They show wide ecological diversity and include species that are used for promoting plant growth and bio-control as well species that are opportunistic pathogens of vulnerable patients. Over recent years the Bcc have emerged as problematic pathogens of the CF lung. Pseudomonas aeruginosa is another important CF pathogen. It is able to synthesise hydrogen cyanide (HCN), a potent inhibitor of cellular respiration. We have recently shown that HCN production by P. aeruginosa may have a role in CF pathogenesis. This paper describes an investigation of the ability of bacteria of the Bcc to make HCN. |
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