A Mathematical Model for the Effects of HER2 Over-Expression on Cell Cycle Progression in Breast Cancer |
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| Authors: | Amina Eladdadi David Isaacson |
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| Affiliation: | (1) Cancer Proteomics Laboratory, EGA Institute for Women's Health, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK;(2) Ludwig Institute for Cancer Research, Cruciform Building, Gower Street, London, WC1E 6BT, UK;(3) Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Cruciform Building, Gower Street, Hsinchu, Taiwan |
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| Abstract: | ![]()
In this paper, we present a mathematical model predicting the fraction of proliferating cells in G1, S, and G2/M phases of the cell cycle as a function of EGFR and HER2. We show that it is possible to find parameters for the mathematical model so that its predictions agree with the experimental observations that HER2 over-expression results in: (1) a shorter G1-phase and early S-phase entry; (2) and that with a 1-to-1 ration between EGFR and HER2, the growth advantage in HER2 over-expressing cells is indeed associated with the increase of the HER2 expression level. |
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