| 内毒素对人血小板聚集,释放的体外作用 |
| |
| 引用本文： | 何坎 刘怀琼. 内毒素对人血小板聚集,释放的体外作用[J]. 生理学报, 1990, 42(6): 591-594 |
| |
| 作者姓名： | 何坎 刘怀琼 |
| |
| 作者单位： | 第三军医大学大坪医院 重庆(何坎),第三军医大学大坪医院 重庆(刘怀琼) |
| |
| 摘 要： | 大肠杆菌 O55B5内毒素在体外可抑制人血小板自发性聚集,并使血小板内 cAMP、钙调素明显增高,但对肾上腺素诱发的血小板聚集无作用,也不能引起血小板致密颗粒和α-颗粒的释放。此外还观察到内毒素组无血小板上清液中5-HT 含量减少。
|
| 关 键 词： | 血小板 内毒素 |
EFFECT OF ENDOTOXIN ON AGGREGATION AND RELEASE OF HUMAN PLATELET IN VITRO |
| |
| HE KAN,LIOU HUAI-QION G. EFFECT OF ENDOTOXIN ON AGGREGATION AND RELEASE OF HUMAN PLATELET IN VITRO[J]. Acta Physiologica Sinica, 1990, 42(6): 591-594 |
| |
| Authors: | HE KAN LIOU HUAI-QION G |
| |
| Affiliation: | Daping Hospital, Third Military Medical College, Chongqing. |
| |
| Abstract: | The effect of endotoxin on human platelet was studied in vitro. E Coli O55B5 endotoxin inhibited spontaneous platelet aggregation but had no effect on platelet aggregation by epinephrine and the release of contents from dense granule, alpha-granule of platelet. The endotoxin also elevated cAMP and increased the activity of calmodulin in platelet, which might account for the effect of the endotoxin on platelet. In addition, a reduced concentration of 5-HT in the supernate of endotoxin group was also observed. |
| |
| Keywords: | platelet endotoxin cAMP calmodulin |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
