Endothelial Dysfunction in Rheumatoid Arthritis: Mechanistic Insights and Correlation with Circulating Markers of Systemic Inflammation |
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| Authors: | Perle Totoson Katy Maguin-Gaté Maude Nappey Daniel Wendling Céline Demougeot |
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| Affiliation: | 1EA 4267 FDE, FHU INCREASE, Univ. Bourgogne Franche-Comté, Besançon, France;2Service de Rhumatologie, CHRU Besançon, Besançon, France;3EA 4266, Univ. Bourgogne Franche-Comté, Besançon, France;University of Iowa, UNITED STATES |
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| Abstract: | ![]()
ObjectivesTo determine mechanisms involved in endothelial dysfunction (ED) during the course of arthritis and to investigate the link between cytokines, chemokines and osteoprotegerin.ConclusionsOur data identified increased endothelial NOS activity as an important compensatory response that opposes the ED in the early arthritis. Thereafter, a cross-talk between endothelial COX-2/NOS pathways appears as an important element for the occurrence of ED. Our results encourage determining the clinical value of IL-1β, TNFα and MIP-1α as biomarkers of ED in RA. |
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