A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus |
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Authors: | Zhao Yuguang Yao Yongxiu Xu Hongtao Lambeth Luke Smith Lorraine P Kgosana Lydia Wang Xiaowei Nair Venugopal |
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Institution: | Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom. |
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Abstract: | Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis. |
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