The role of calcium in the induction of ornithine decarboxylase in rat HTC cells |
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| Authors: | Z N Canellakis T C Theoharides P K Bondy E T Triarhos |
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| Affiliation: | 1. Veterans Administration Medical Center, West Haven, CT 06516, USA;2. Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA;3. Pharmacology Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA |
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| Abstract: | The possible role of calcium ions in the induction of ornithine decarboxylase (ODC) in rat hepatoma cells in culture (HTC) has been investigated by manipulating cellular calcium levels as follows: a) use of the calcium chelating agent EGTA to inhibit induction of ODC by dibutyryl cyclic AMP (cAMP), b) addition of Ca++ to reverse the inhibition of cAMP induction of ODC by EGTA, c) use of a calcium ionophore in the presence of Ca++ to induce ODC. In each case there was positive evidence for the participation of Ca++ in the induction of ODC. |
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| Keywords: | To whom reprint requests may be addressed. |
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