<Emphasis Type="Italic">R-spondin1</Emphasis> and <Emphasis Type="Italic">FOXL2</Emphasis>act into two distinct cellular types during goat ovarian differentiation |
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| Authors: | Ayhan Kocer Iris Pinheiro Maëlle Pannetier Lauriane Renault Pietro Parma Orietta Radi Kyung-Ah Kim Giovanna Camerino Eric Pailhoux |
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| Institution: | 1.INRA, UMR 1198, ENVA, CNRS, FRE 2857, Biologie du Développement et de la Reproduction,Jouy-en-Josas,France;2.Dipartimento di Patologica Umana ed Ereditaria,Università di Pavia,Pavia,Italy;3.Nuvelo, Inc.,Sunnyvale,USA |
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| Abstract: | Background Up to now, two loci have been involved in XX sex-reversal in mammals following loss-of-function mutations, PIS (Polled Intersex
Syndrome) in goats and R-spondin1 (RSPO1) in humans. Here, we analyze the possible interaction between these two factors during goat gonad development. Furthermore,
since functional redundancy between different R-spondins may influence gonad development, we also studied the expression patterns of RSPO2, 3 and 4. |
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