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Biomarker profiles in serum and saliva of experimental Sj?gren's syndrome: associations with specific autoimmune manifestations
Authors:Nicolas Delaleu  Heike Immervoll  Janet Cornelius and Roland Jonsson
Institution:(1) Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Haukelandsveien, Bergen, 5021, Norway;(2) Section of Pathology, The Gade Institute, University of Bergen, Jonas Liesvei, Bergen, 5021, Norway;(3) Department of Pathology, Haukeland University Hospital, Jonas Liesvei, Bergen, 5021, Norway;(4) Department of Pathology, Immunology and Laboratory Medicine, University of Florida, SW Archer Road, Gainesville, FL 32610, USA;(5) Department of Rheumatology, Haukeland University Hospital, Jonas Liesvei, Bergen, 5021, Norway;(6) Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Jonas Liesvei, Bergen, 5021, Norway
Abstract:

Introduction  

Sj?gren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins analyzed in saliva in spontaneous experimental SS. In addition, we intended to compute a model of the immunological situation representing the overt disease stage of SS.
Keywords:
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