In infertile women,cells from <Emphasis Type="Italic">Chlamydia trachomatis</Emphasis> infected site release higher levels of interferon-gamma,interleukin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation than fertile women |
| |
Authors: | Pragya Srivastava Rajneesh Jha Sylvette Bas Sudha Salhan Aruna Mittal |
| |
Institution: | (1) Institute of Pathology – ICMR, Safdarjung Hospital Campus, Post Box no. 4909, 110 029 New Delhi, India;(2) Division of Rheumatology, Department of Internal Medicine, University Hospital, 1211 Geneva 14, Switzerland;(3) Department of Gynecology & Obstetrics, Safdarjung Hospital, 110 029 New Delhi, India |
| |
Abstract: | Background The magnitude of reproductive morbidity associated with sexually transmitted Chlamydia trachomatis infection is enormous.
Association of antibodies to chlamydial heat shock proteins (cHSP) 60 and 10 with various disease sequelae such as infertility
or ectopic pregnancy has been reported. Cell-mediated immunity is essential in resolution and in protection to Chlamydia as
well as is involved in the immunopathogenesis of chlamydial diseases. To date only peripheral cell mediated immune responses
have been evaluated for cHSP60. These studies suggest cHSPs as important factors involved in immunopathological condition
associated with infection. Hence study of specific cytokine responses of mononuclear cells from the infectious site to cHSP60
and cHSP10 may elucidate their actual role in the cause of immunopathogenesis and the disease outcome. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|