The uptake and efflux of glycine from rat cerebral-cortex slices |
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| Authors: | P. Joanny E. Barbosa H. Hillman J. Corriol |
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| Affiliation: | Laboratoire de Physiologie, U.E.R. de Medecine, Section Nord, Marseille, France, and Department of Biological Sciences, University of Surrey, Guildford, Surrey, U.K. |
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| Abstract: | The kinetics of the influx and efflux of radioactive l-glycine was studied in slices of rat cerebral cortex. The influx showed saturation kinetics and was inhibited by l-alanine. Influx was dependent on the presence of Na(+) ions and a metabolizable substrate. The efflux of glycine was accelerated by alanine. It was concluded that carrier-mediated facilitated diffusion was the mechanism of glycine uptake by, and efflux from, cerebral slices. |
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