Signaling by discoidin domain receptor 1 in cancer metastasis |
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Authors: | Mayur Gadiya |
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Institution: | 1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA |
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Abstract: | ABSTRACTCollagen is the most abundant component of tumor extracellular matrix (ECM). ECM collagens are known to directly interact with the tumor cells via cell surface receptor and play crucial role in tumor cell survival and promote tumor progression. Collagen receptor DDR1 is a member of receptor tyrosine kinase (RTK) family with a unique motif in the extracellular domain resembling Dictyostelium discoideum protein discoidin-I. DDR1 displays delayed and sustained activation upon interaction with collagen and recent findings have demonstrated that DDR1-collagen signaling play important role in cancer progression. In this review, we discuss the current knowledge on the role of DDR1 in cancer metastasis and possibility of a potential therapeutic approach of DDR1 targeted therapy in cancer. |
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Keywords: | DDR1 TM4SF1 Metastasis Dormancy Cell Signaling |
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