Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells |
| |
Authors: | Kena Lv Shuangshuang Zheng Xiangqin Li Yi Nie Tianqing Liu Kedong Song |
| |
Institution: | 1 State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China2 Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou, 450000, China3 Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China |
| |
Abstract: | As one of the adjuvant treatments for cancer treatment, traditional Chinese medicine treatment has a wide range of cancer treatments, such as preventing
metastasis and relapse, improving the efficacy of radiotherapy and chemotherapy,
reducing the side effects of chemotherapy, improving body function, extending
life and improving the life quality. Geniposide (GEN) is a bioactive substance
extracted from the fruit of gardenia. In recent years, it has attracted attention
due to its anti-tumor effect. In this study, we aimed to investigate whether
GEN could inhibit the proliferation of human breast cancer cells (MCF-7) and
promote its apoptosis. The half-inhibitory concentration (IC50) values of GEN
were firstly determined as 16.06, 14.85 and 13.14 mg/mL by the CCK-8 experiment after cells treated for 24 h, 48 h, and 72 h, respectively. The inhibitory effect
of GEN on MCF-7 cells was in concentration- and time-dependent manners from
the results of CCK-8 experiment and Live/Dead staining. AO/EB staining result
has shown that GEN has induced MCF-7 cell apoptosis. |
| |
Keywords: | MCF-7 geniposide anti-cancer |
|
| 点击此处可从《Molecular & cellular biomechanics : MCB》浏览原始摘要信息 |
| 点击此处可从《Molecular & cellular biomechanics : MCB》下载免费的PDF全文 |
|