COVID-19疫苗研究现状*

2019年底于中国武汉暴发的新型冠状病毒肺炎疫情来势凶猛,迅速蔓延全球,并被世界卫生组织列为“国际关注的突发公共卫生事件”,给全人类的健康及经济发展造成难以估量的损害。新型冠状病毒对人群普遍易感且传染性强,在无特效药物及治疗手段的情况下,疫苗接种是防控COVID-19疫情最有效且最经济的途径。目前全球疫苗研发正在加速进行,各国之间通力合作,共同应对此次疫情。主要对目前正在研发的针对SARS-CoV-2的灭活疫苗、病毒载体疫苗、基因工程重组亚单位疫苗、核酸疫苗的研究进展进行综述。

The Progress in the Development of COVID-19 Vaccine

Breaking out in Wuhan, China at the end of year 2019, coronavirus disease 2019 (COVID-19) rapidly spread around the world. It was listed as a “public health emergency of international concern” by WHO and has caused incalculable damage to human health and economic development. Humans are generally susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that causes COVID-19. In the lack of specific drugs and treatments, vaccination is the most effective and economical way to prevent and control COVID-19. At present, the vaccines against SARS-CoV-2 are being developed in many countries, which work together to cope with the epidemic. This paper mainly reviews the research advances in the vaccines against SARS-CoV-2, i.e., inactivated vaccine, viral vector vaccine, genetic engineering recombinant subunit vaccine, and nucleic acid vaccine.