Survival of cultured mammalian cells exposed to ultrasound |
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| Authors: | B. I. Martins M. R. Raju T. L. Hayes C. A. Tobias |
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| Affiliation: | (1) Section of Radiobiology and Physics, University of Maryland Hospital, 21201 Baltimore, MD, USA;(2) Biophysics and Instrumentation Group, University of California Los Alamos, 87544 Los Alamos, NM, USA;(3) Donner Laboratory, Division of Biology and Medicine, Lawrence Berkeley Laboratory, University of California, 94720 Berkeley, CA, USA |
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| Abstract: | Summary The colony-forming ability of cultured mammalian cells exposed to monochromatic ultrasonic vibrations of different frequencies (0.1, 0.5, 1.0, 2.0, 3.3 MHz) was studied. The combined effect of x rays and 1.0-MHz ultrasonic waves on the survival of M3-1 cells was also investigated. Split-dose experiments showed that cells exposed to ultrasound are  sensitized to a subsequent exposure. Almost twice as many cells survive a given ultrasonic dose when exposed in the M phase as when exposed in the S phase. A small amount of synergism between ultrasound and x rays has been observed. The extent of synergism depends on the experimental factors, and may be due to an interaction between nuclear damage caused by x rays and the damage to the cell membrane caused by ultrasound.Research supported by the U.S. Atomic Energy Commission and the National Aeronautics and Space Administration |
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