喹诺酮信号系统研究进展

喹诺酮信号系统是铜绿假单胞菌群体感应调控网络中一个重要组成部分,对于绿脓菌素和弹性蛋白酶等毒力因子的表达及细菌生物被膜形成和细菌运动具有重要的调控作用,因此与临床细菌感染密切相关。3,4-二羟基-2-庚基-喹诺酮(Pseudomonas quinolone signal,PQS)及2-庚基-4喹诺酮(4-hydroxy-2-heptylquinoline,HHQ)是pqs调控系统中重要的信号分子。PQS对于细菌在压力下群体密度及细菌物质运输具有调控作用,从而增强细菌对于环境的适应能力。同时PQS等分子在一定程度上抑制了人体的免疫系统,帮助细菌在宿主体内生存。HHQ在其他革兰氏阴性细菌及革兰氏阳性细菌中也有合成并发挥调控作用,所以喹诺酮信号分子不仅是种内也是种间交流媒介。将喹诺酮系统作为靶点降低细菌的信号交流是抑制细菌感染的一个新思路。本文对喹诺酮信号系统进行概述。

The Research on the Regulatory Function of the Pqs QuorumSensing System

Pseudomonas aeruginosa is an opportunistic pathogen. Diverse virulence Factors and secondary metabolites are regu-lated by a hierarchical quorum sensing system. There are three quorum sensing systems, named las, rhl and pqs. The pqs system plays an important role in quorum sensing regulatory network and it regulates the expression of virulence factor genes such as pyocyanin and elas- tase. The biofilm formation and swarming activity are regulated by the pqs system. The quorum sensing molecules of the pqs system in-eludes 3,4-dihydroxy-2-heptyl-quinolone named Pseudomonas quinolone signal （PQS） and 4-hydroxy-2-heptylquinoline （HHQ）. PQS is a multifunctional molecule which plays a role in an autolytic process under stressful conditions. PQS is also associated with the transport. HHQ is synthesized in other gram-negative bacteria and gram-positive bacteria. It is the potential for treating bacterial infections by dis-rupting the pqs system, This article is a review of the pqs quorum sensing system.