脂肪因子与代谢综合征关系的研究进展

代谢综合症是一系列代谢和心血管功能失调的临床特征,包括中心性肥胖、高血压、血脂异常、高血糖及胰岛素抵抗等,其发病机制及如何预防及控制代谢综合症正日益成为目前的学术热点。目前已经公认,脂肪不仅是能量存储器官,也是一个重要的内分泌器官。脂肪组织分泌的生物活性分子被称为脂肪因子。近年来的研究表明,脂肪因子广泛参与肥胖、2型糖尿病、高血压病及心血管疾病等一系列代谢相关性疾病的病理生理过程。脂肪因子能通过介导一系列的信号转导通路,并广泛参与机体复杂的代谢平衡网络的调节。脂肪因子的失衡能导致机体发生对胰岛素敏感性改变等一系列的生物学反应,从而在肥胖和代谢综合症的病理过程中发挥重要的作用。本文综述了脂肪因子与代谢综合征的关系的研究进展。

The Association Between Adipokines and Metabolic Syndrome

The clinical features of metabolic syndrome is a series of metabolic and cardiovascular dysfunction, including central obesity, hypertension, dyslipidemia, high blood sugar and insulin resistance, its pathogenesis and how to prevent and control the metabolic syndrome is increasingly becoming academic hotspot. It is well known that visceral adipose tissue fimctions as an important endocrine organ rather than only fat storage depot. The bioactive molecules secreted from visceral adipose tissues were referred to as adipokines. Recent studies have demonstrated that adipokines were extensively implicated in the pathophysiologic processes of the metabolic disorders such as obesity, type 2 diabetes, hypertension and cardiovascular diseases. Here, we review the recent progress regarding the association between adipokines and metabolic syndrome.