角质细胞生长因子(KGF)研究进展

角质细胞生长因子(KGF)属于成纤维细胞生长因子(FGFs)家族的成员之一,又称FGF一7,最早由Rubin等(1980)从人类胎肺成纤维细胞培养液中分离提纯获得的。人KGF的cDNA编码一含194个氨基酸的单链多肽,其分子量为26-28KD。KGF由各种来源的间质细胞分泌,与肝素有较强的亲和力,其受体KGFR属于蛋白酪氨酸激酶受体家族,目前已知该家族主要包括FGFR1、FGFR2、FGFR3和FGFR4四位成员,KGFR由FGFR2基因编码,为FGFR-2的剪接形式,即FGFR2Ⅲb,其主要分布于上皮细胞,KGF与靶细胞膜上的受体KGFR特异性结合后,促使受体自身磷酸化,从而启动细胞内信号级联反应,进而发挥多种生物学功能:参与组织器官发育、促进细胞增殖及组织损伤修复、减少放化疗引起的副反应,尤其与癌症的发生发展有着密切的联系。该文就KGF的研究进展进行综述。

Advances in Research for the Role of Keratinocyte Growth Factor

Keratinocyte growth factor (KGF, fibroblast growth factor-7 (FGF-7) was first isolated from the conditioned medium of the human embryonic lung fibroblast cell line, which was purified as a monomeric polypeptide with an apparent molecular mass of 26-28 kDa. KGF is a strong affinity for Heparin and mainly synthesized by mesenchymal cells. KGF receptor (KGFR), a member of the tyrosine kinase receptors family including FGFR1, FGFR2, FGFR3 and FGFR4, is encoded by IIIb variants of the BEK/FGFR2 gene (FGFR2b), which is expressed exclusively by various types of epithelial cells. it has been extensively proved that KGF exerts its biological functions through binding to its specific receptor KGFR, including stimulating gcell proliferation, migration, and differentiation in response to injury and tissue repair, especially also correlating with the development of the tumor.