miR-450a-5p在浆液性卵巢癌中的表达及临床意义

目的:检测miR-450a-5p在浆液性卵巢癌中的表达情况,并分析miR-450a-5p的表达与浆液性卵巢癌临床病理特征之间的关系,探讨其在浆液性卵巢癌发生、发展中的意义。方法:采用实时荧光定量PCR技术,检测101例浆液性卵巢癌组织及对照50例正常输卵管伞端组织中miR-450a-5p的表达情况,并分析miR-450a-5p表达水平与临床病理特征之间的关系。实验数据采用统计学软件进行分析。结果:miR-450a-5p在浆液性卵巢癌组织中的表达量显著低于正常输卵管组织对照组(P0.01)。miR-450a-5p的表达水平与浆液性卵巢癌临床病理特征之间差异均无统计学意义(P0.05)。结论:miR-450a-5p可能作为抑癌基因,在卵巢癌的发生、发展中发挥重要作用,进一步的研究有望为浆液性卵巢癌的早期诊断及个体化治疗提供新的理论依据。

The Expression and Clinical Significance of miR-450a-5p in Serous Ovarian Cancer*

Objective： To investigate the expression of miR-450a-5p in serous ovarian cancer, and analyze the correlation of its expression with clinicpathological features and investigate the significance of miR-450a-5p in ovarian cancer carcinogenesis and development. Methods： Quantitative real-time PCR was used to assess the expression of miR-450a-5p in 101 serous ovarian cancer tissues and 50 normal fimbria of fallopian tube tissues, and the results were assessed with statistic analysis. Results： The expression of miR-450a-5p in serous ovarian cancer tissues down-regulated significantly than that in normal funbria of fallopian tube tissues （P 〈 0.01）. There was no significant difference for expression ofmiR-450a-5p with clinicopathological features in serous ovarian cancer （P〉 0.05）. Conclusion： miR-450a-5p may play an important role as a tumor-suppressor in the occurrence and development of serous ovarian cancer and may provide new basic theories for the earlier diagnosis and target treatment of serous ovarian cancer.