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Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes |
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| Authors: | Nicola J Patron Ross F Waller Anton J Cozijnsen David C Straney Donald M Gardiner William C Nierman Barbara J Howlett |
| Institution: | (1) Department of Botany, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada;(2) School of Botany, the University of Melbourne, Victoria, 3010, Australia;(3) Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA;(4) CSIRO Plant Industry, 306 Carmody Rd, St Lucia, 4072, QLD, Australia;(5) J. Craig Venter Institute, 9704 Medical Center Drive, 20850 Rockville, MD, USA;(6) Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, DC 20037, USA |
| Abstract: | BackgroundGenes responsible for biosynthesis of fungal secondary metabolites are usually tightly clustered in the genome and co-regulated with metabolite production. Epipolythiodioxopiperazines (ETPs) are a class of secondary metabolite toxins produced by disparate ascomycete fungi and implicated in several animal and plant diseases. Gene clusters responsible for their production have previously been defined in only two fungi. Fungal genome sequence data have been surveyed for the presence of putative ETP clusters and cluster data have been generated from several fungal taxa where genome sequences are not available. Phylogenetic analysis of cluster genes has been used to investigate the assembly and heredity of these gene clusters. |
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