Cellular effects of 5-formyluracil in DNA. |
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| Authors: | S Bjelland H Anensen I Knaevelsrud E Seeberg |
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| Affiliation: | School of Science and Technology, Stavanger University College, Ullandhaug, P.O. Box 2557, N-4091 Stavanger, Oslo, Norway. svein.bjelland@tn.his.no |
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| Abstract: | ![]()
5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to gamma-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage. |
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