Q192R polymorphism of PON-1 gene in type 2 diabetes patients |
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| Authors: | M. Yu. Gorshunskaya Yu. I. Karachentsev L. A. Atramentova T. V. Tyzhnenko N. A. Kravchun A. K. Pochernyaev V. V. Poltorak |
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| Affiliation: | (1) Department of Neuroscience, The Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey;(2) Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey;(3) Department of Cardiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey;(4) Eyup State Hospital, Istanbul, Turkey |
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| Abstract: | ![]()
The Q192R polymorphism of PON-1 gene was genotyped in 96 individuals with diabetes mellitus type 2 (T2DM) and 123 nondiabetic control individuals from Kharkiv. Allele frequencies do not differ significantly between T2DM (p Q = 0.65 and p R = 0.35) and healthy individuals (p Q = 0.70 and p R = 0.30). Genotype distribution for healthy people complies with the Hardy-Weinberg equilibrium, and the T2DM patients have excess of both homozygotes and deficiency of heterozygotes. The risk of T2DM for QQ homozygotes is 1.47 times higher and for QR heterozygote is twice lower than the population average (2%). The RR homozygote individuals have statistically insignificant, 1.86 times, increase in T2DM risk. |
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