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The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein
Institution:1. Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan;2. Département de Biochimie et Médicine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada;1. Département de Biochimie et Médicine Moléculaire, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada;2. Department of Biochemistry, Beni-Suef University, Beni-Suef 62521, Egypt;3. Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan;1. Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, North 10, West 8, Kita-ku, Sapporo 060-0810, Japan;2. Laboratory of Organic Chemistry II, Department of Chemistry, Faculty of Science, Hokkaido University, North 10, West 8, Kita-ku, Sapporo 060-0810, Japan;1. Department of Human Genetics, Donders Centre for Neuroscience, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands;2. Cancer Research UK Gene Function Laboratory and Breast Cancer Now Research Centre, Institute of Cancer Research, London SW3 6JB, UK;3. Department of Genetics, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands;4. Departments of Neurology, Pediatrics, and Psychiatry, University of California, San Francisco, 675 Nelson Rising Lane, Suite 405, San Francisco, CA 94143, USA;5. Division of Pediatric Genetics, Metabolism & Genomic Medicine, University of Michigan Medical School, D5257 Medical Professional Building, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5718, USA;6. Division of Medical Genetics, Department of Pediatrics, UCSF Benioff Children’s Hospital, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143-0793, USA;7. Clinical Genetics, Children’s University Hospital, Temple Street, Dublin 1, Ireland;8. Academic Centre on Rare Diseases, School of Medicine and Medical Sciences, University College Dublin, Dublin 1, Ireland;9. Department of Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK;10. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK;11. North West Thames Regional Genetic Service (Kennedy Galton Centre), North West London Hospitals, Watford Road, London HA1 3UJ, UK;12. Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK;13. West Midlands Regional Clinical Genetics Service and Birmingham Health Partners, Birmingham Women’s Hospital NHS Foundation Trust, Birmingham B15 2TG, UK;14. Department of Clinical Genetics, University Hospitals Bristol NHS Foundation Trust, St. Michael’s Hospital, Southwell Street, Bristol BS2 8EG, UK;15. Center on Human Development and Disability, University of Washington, PO Box 357920, Seattle, WA 98195-7920, USA;16. Department of Clinical Genetics, Karolinska University Hospital Solna, Karolinska Institutet, 171 77 Stockholm, Sweden;17. Department of Medicine and Neurology, Habilitation Organization, Region Skåne, 291 89 Kristianstad, Sweden;18. Department of Clinical Genetics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands;19. GeneDx, Gaithersburg, MD 20877, USA;20. Department of Clinical Genetics, Maastricht University Medical Centre, Universiteitssingel 50, 9229 ER Maastricht, the Netherlands;1. Laboratory of Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Grant S-047, Stanford, CA 94305, USA;2. Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA 94305, USA;1. Department of Oncology, University of Torino School of Medicine, Turin, Italy;2. Candiolo Cancer Institute, Fondazione del Piemonte per l''Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), SP 142, Km. 3.95, 10060 Candiolo, Italy
Abstract:
Keywords:Evolution  Structure  Tetramerization  Tumor suppressor protein p53  CD"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"circular dichroism  WT"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"wild-type  p53Tet"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"human p53 tetramerization domain  tree shrew p53 tetramerization domain  p53TetQ354?M"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"Q354?M variant of human p53 tetramerization domain  M354Q variant of tree shrew p53 tetramerization domain
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